Series
AY 2015

Brain Science – from Synapses to the Meaning of Life (Global Focus on Knowledge)

Coordinator: Tetsuya Tabata (Institute of Molecular and Cellular Biosciences),        Hiroki Ueda (Faculty of Medicine) Navigator: Tatsuo Michiue (College of Arts and Sciences) Our activities such as thinking, remembering the past, and dreaming are, needless to say, functions of the brain. But what goes on in the brain’s vast neural network during these activities? To find out, not only humans but also various species from monkeys, mice, and rats to even nematodes and fruit flies are used as model animals for different kinds of research methods, such as electrophysiology, biochemistry and cell biology for studying functions of molecules at synapses, imaging using microscopes and fMRI, genetically modified animals, and mathematical analyses. Our experts in each field will introduce these wide-ranging approaches in an easy-to-understand manner and wrap up their lectures by discussing how progress in brain science contributes to the understanding of our existence from the standpoint of philosophy of science. Does the brain know the brain itself? At the end of this lecture series, all of you will be more optimistic that understanding functions of the brain at the level of cellular signal transmission will be achieved in the near future. You may even consider devoting yourself to such studies. We welcome all students on Komaba Campus, regardless of their affiliation or major, hoping that this course will provide you with help to understand the meaning of our lives.

Content List

00:23
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Introduction – Brain Science

Lecturer | Tetsuya Tabata
00:23
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1:15
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#1 Brain Decoding and Brain-Machine Interface(1)

Brain signals can be regarded as “codes” that represent mental states. We will introduce the ways of “decoding” these signals using methods of information science, and techniques for manipulating machines and computers based on the decoded information.

Lecturer | Yukiyasu Kamitani
1:15
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1:49
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#2 Brain Decoding and Brain-Machine Interface(2)

Lecturer | Yukiyasu Kamitani
1:49
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1:46
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#4 Molecules and Circuits that Generate Behavioral Plasticity

The most important function of the brain’s nervous system is the ability to change behavior depending on environmental situations based on past experiences. What roles does each neuron play in producing these behavioral plasticities? We will discuss findings from research on nematodes, which allows high-resolution analyses thanks to its compact nervous system.

Lecturer | Yuichi Iino
1:46
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1:40
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#5 A Global Focus on a Small Brain

The fruit fly has a very small brain, the neural activities of which can be observed under a microscope. We will introduce part of ongoing efforts to understand the memory mechanisms with this kind of experiment.

Lecturer | Tetsuya Tabata
1:40
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1:44
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#6 Understanding Cellular Activities Observed Alive in the Brain

Technology is making dramatic progress in observing individual cells in the brains of living animals communicating with one another to work together. We will explain in detail how this is possible and what can be learned from it.

Lecturer | Masamitsu Iino
1:44
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1:42
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#8 Neural Basis of Emotions and Value-based Decisions

Humans by nature have emotions such as likes and dislikes. We can also suddenly hate something that we previously loved, and vice versa. How does our brain decide what we like and dislike? Do lower organisms like insects have similar systems in their brains? We will explain the brain mechanisms for emotions and value-based decisions in animals.

Lecturer | Kazuo Enomoto
1:42
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1:50
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#9 Computational Nuroscience – Models and Analyses, Mathematical Models Describing Brain Activity

Rapid advances in experimental technology have enabled us to measure and manipulate activities of a large number of neurons in the brain. How can we understand brain functions based on these big and complex data? In this lecture, we will introduce analytical techniques from physics and information theory to investigate key functional properties for neuronal circuits that can relate diverse experi…

Lecturer | Taro Toyoizumi
1:50
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1:55
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#10 Computational Nuroscience – Models and Analyses, Mathematical Models Describing “Learning”

Lecturer | Taro Toyoizumi
1:55
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1:49
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#11 False Memories and Real Memories – Encoding of Information by Neuronal Cell Populations

Are your memories real!?This lecture will present latest research on how memories are stored in the brain. Now it is possible to create new memories by artificially combining different old memories. We will also talk about cutting-edge research in brain science that focuses on the “medicine of memory” to control traumatic memories. What if human beings succeed in creating memories that they have …

Lecturer | Kaoru Inokuchi
1:49
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2:02
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#13 Seamless Connection between Philosophy and Biology

The development of life science and cognitive science has made scientists address the question of what human beings are. Above all, the mind, values, and ethics – once considered the exclusive domains of philosophy – have also become the subjects of science. How should philosophy deal with such issues? Through examples we will discuss how traditional philosophical questions can become even more i…

Lecturer | Kazuhisa Todayama
2:02
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